Ok, on your frameset page do this:
<html><frameset rows="25%,75%" border="1"><frame src="frame_a.htm"><frameset cols="15%,85%" border="1"><frame src="frame_b.htm" name="links"><frame src="frame_c.htm" name="content"></frameset></frameset><head><title>Hoofdpagina</title></head><body></body></html>
Then on page B, the link should be:
<p><a href="home.htm" target="content"><img src="http://i10.tinypic.com/2u5cllz.jpg" border="0" /></a></p>
That will change the web page in the content frame from "frame_c.htm" to "home.htm"